Proteome-wide mendelian randomization
Webb12 dec. 2024 · Integration of large-scale protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus connected genetic variation to disease … Webb11 mars 2024 · We identify and prioritise blood proteins and biomarkers that may indicate increased risk for severe COVID-19, via a proteome Mendelian randomization approach by collecting genome-wide association study (GWAS) …
Proteome-wide mendelian randomization
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Webb31 jan. 2024 · Since obesity influences the plasma proteome, we sought to identify circulating proteins mediating the effects of obesity on COVID-19 severity in humans. Here, we screened 4,907 plasma proteins to identify proteins influenced by body mass index (BMI) using Mendelian randomization (MR). Webb期刊：Gastroenterology文献作者：Jérome Bourgault; Erik Abner; Hasanga D. Manikpurage; Natàlia Pujol-Gualdo; Triin Laisk; Emilie Gobeil; Eloi Gagnon; Arnau ... Proteome-Wide Mendelian Randomization Identifies Causal Links …
Webb8 juni 2024 · Obesity is a major risk factor for COVID-19 severity; however, the underlying mechanism is not fully understood. Considering that obesity influences the human plasma proteome, we sought to identify circulating proteins mediating the effects of obesity on COVID-19 severity. We first screened 4,907 plasma proteins to identify proteins … Webb20 feb. 2024 · Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity Request PDF Proteome-wide Mendelian randomization...
Webb1 feb. 2024 · Request PDF Proteome-Wide Mendelian Randomization Identifies Causal Links Between Blood Proteins and Acute Pancreatitis Background: Acute pancreatitis (AP) is a complex disease and the leading ...
Webb1 feb. 2024 · Proteome-Wide Mendelian Randomization Identifies Causal Links Between Blood Proteins and Acute Pancreatitis - ScienceDirect Abstract Section snippets References (57) Recommended articles (6) Gastroenterology Available online 1 February 2024 In Press, Corrected Proof What’s this?
Webb3 mars 2024 · We applied Mendelian randomization including >3,000 blood proteins as exposures to identify potential biomarkers that may indicate risk for hospitalization or … mandala flower tattoo menWebb9 mars 2024 · Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19 Alish B. Palmos1,2*†, Vincent Millischer3,4†, DavidK.Menon5, Timothy R. Nicholson2,10, Leonie Taams6, Benedict Michael8, COVID Clinical NeuroscienceStudy Consortium, Christopher Hübel1,2,9‡and Gerome Breen1,2‡ … mandala flower clipartWebb13 dec. 2024 · Proteome-wide and transcriptome-wide associations were determined by functional summary-based imputation leveraging data from genome-wide association summary (56 306 Europeans, 1.4 million controls), brain proteomes (528 cases from 2 separate data sets), and transcriptome (452 cases), followed by Mendelian … crispin and crispinianWebb14 nov. 2024 · Colocalization, gene expression profiling, and Mendelian randomization provide convergent evidence for the roles of BCKDHA and circulating branch-chain amino acids in heart failure and cardiac structure. Finally, proteome-wide Mendelian randomization identifies 9 circulating proteins associated with heart failure or … mandala fondo transparenteWebbTherapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses Therapeutic targets for inflammatory bowel … crispin apple originWebbför 2 dagar sedan · To assess potential causality, Mendelian randomization analyses showed that genetic predisposition to CHIP was associated with a greater risk of chronic liver disease (odds ratio = 2.37, 95% CI [1 ... crispin apples delivery near meWebbapproach with Mendelian randomization (MR) might constitute attractive targets for potential therapeutics. Added value of this study In the current study, we conducted a … mandala format a4 a imprimer