WebJul 4, 2024 · Structure–activity optimization yielded more potent MCB analogs, which led to the identification of phosphatidylinositol transfer proteins α and β (PITPα/β) as the direct … WebFeb 12, 2008 · The deduced 1,244-amino acid PITPNM1 protein shares structural domains with other family members, including an N-terminal phosphatidylinositol (PI) transfer …
Structure of a Multifunctional Protein - Journal of Biological …
WebEukaryotic phosphatidylinositol transfer protein is a ubiquitous multifunctional protein that transports phospholipids between membrane surfaces and participates in cellular phospholipid metabolism during signal transduction and vesicular trafficking. The three-dimensional structure of the α-isoform of rat phosphatidylinositol transfer protein … WebJul 30, 2013 · Here we show that the phosphatidylinositol (PI)-transfer protein Nir2 translocates from the Golgi complex to the plasma membrane in response to GF stimulation. This translocation is triggered by PA formation and is mediated by its C-terminal region that binds PA in vitro. We further show that depletion of Nir2 substantially reduces … fisher plow hydraulic hose kit
Sec14-like phosphatidylinositol transfer proteins and the …
WebAug 5, 2024 · A protein that helps move lipids within cells — phosphatidylinositol transfer protein — seems to be a key regulator in the migration of cortical neurons during development and may play a role in neurodevelopmental conditions. ... An artificial-intelligence tool from the company Deep Mind has predicted the shape of 200 million … WebMay 31, 2024 · Herein, we find that the disproportional expansion of the developing neocortex reflects an integration of phosphatidylinositol transfer protein (PITP) signaling, non-canonical planar cell polarity signaling (ncPCP) and IKNM in NSCs. Two highly homologous PITPs (PITPNA and PITPNB) support development of the mammalian … WebJan 23, 2007 · Phosphatidylinositol transfer protein alpha isoform Short names PI-TP-alpha; PtdIns transfer protein alpha; PtdInsTP alpha Gene names Name PITPNA Synonyms … can alcoholism can be cured