WebMar 30, 2024 · IRF8 has a DNA binding domain (DBD; 120 aa) of the helix-turn-helix type and an IRF association domain (IAD) that serves as a recruitment module for other transcription factors. At the molecular level, IRF8 is known to be co-recruited to ternary complexes with other transcription factors (TFs) such as (a) ... WebApr 29, 2024 · This domain is referred to as the IRF association domain (IAD). This IAD motif can be detected in all seven IRFs except IRF-1 and IRF-2. Literature This section has been translated automatically. Green R et al (2024) Interferon-stimulated genes: new platforms and computational approaches. Mamm Genome 29:593-602
Frontiers Therapeutic Targeting of IRFs: Pathway-Dependence or
WebJul 13, 2007 · This protein-protein interaction, occurring through the C-terminal IRF association domain (IAD), extends the range of target genes beyond those carrying ISREs. IRF-4 KO mice are impaired in the maturation of T and B cells, defects most strikingly manifest after antigen stimulation ( 9 ). WebAug 13, 2024 · Structurally, IRF4 comprises two domains, namely, a highly conserved N-terminal DNA binding domain (DBD) and a C-terminal IRF association domain (IAD) linked by a flexible linker (Remesh et al. 2015; Nam and Lim 2016) (Fig. 1A). The DBD is characterised by the presence of five conserved tryptophan residues and underpins target DNA … orbaugh
Structural basis of STAT2 recognition by IRF9 reveals ... - PubMed
WebDavid J. Abraham is designated member of the Appraisal Institute and holds both the MAI and SRA Designations: Licensing: State of Michigan - Certified General Appraiser … WebAmino acid position 80 of IRF8 is within the DNA-binding domain . The threonine residue is strictly conserved across IRF8 orthologues ( Figure 2B ) and human paralogous genes … WebOct 5, 2008 · The physiological importance of IRF5 makes it an important prototype for investigating regulation of IRF proteins. IRF proteins, including IRF5, comprise two major domains, an N-terminal DNA... ipmitool bios boot