WebGene and protein structure. FH is located on chromosome 1 (1q42.3-q43) and is composed of 10 exons.1 2 The FH protein is a 510-amino acid structure with three key domains: a N-terminal lyase 1 domain, a C-terminal fumarase C domain and a central domain which interacts with other FH monomers.1 3 In its functional form, FH exists as a … WebMar 27, 2024 · For example, CHO-produced recombinant human mini-FH or mouse CR2-FH were detectable for around 6 or 9 hours in serum after administered to Cfh−/− mice, respectively, 43, 73 whereas plasma purified human FH was detectable for up to 2 days. 36 In man, human FH (from plasma infusion) was found to have a 6-day t 1/2 in an FH …
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